Dr. Pooja Jadiya

The Jadiya lab focuses on the role and mechanisms of mitochondrial calcium dysregulation and cell death in aging and age-associated neurodegenerative diseases such as Alzheimer's disease. Mitochondrial calcium flux is an essential regulator of mitochondrial functions and metabolism. However, dysregulated mitochondrial calcium signaling can contribute to oxidative stress, mitochondrial and metabolic derangement, and neuronal cell death. To understand how preserving mitochondrial functions and calcium signaling can prevent neuronal pathology and how these mechanisms could be targeted therapeutically, my lab utilizes genetic, loss, and gain-of-function mutant mice, cutting-edge molecular imaging methodologies, calcium flux analysis, mass spectrometry-based profiling (proteomics, metabolomics, lipidomics), rodent behavioral tests, and cellular metabolism measurements.